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Humana Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology)

Name: Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology)
Brand: Humana
Price: 89.12 GBP
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Pharmacy - Dispensing

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Description

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritativeand practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.

Product Specifications

Brand: Humana
Format: paperback
ASIN: 1071615440
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Pharmacy - Dispensing
Domain: Amazon UK
Release Date: 10 July 2022
Listed Since: 13 June 2022

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Humana Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology)

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