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Humana Optimization in Drug Discovery: In Vitro Methods Book

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Description

Optimization in Drug Discovery: In Vitro Methods, Second Edition, provides a comprehensive guide to essential laboratory techniques within the Methods in Pharmacology and Toxicology series. This thoroughly revised and updated volume covers a wide spectrum of in vitro assays required for modern pharmaceutical research. Readers can access detailed information on formulation, plasma binding, absorption, and permeability. The text also covers cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, and drug transporters. Additionally, it addresses drug-drug interactions through the assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Each chapter is structured to include introductions to specific topics and lists of necessary materials, making it a practical resource for professionals in the field of pharmacology and toxicology.

Key Features

This second edition from Humana offers a thoroughly revised and updated look at in vitro assays used in drug discovery.

The text covers essential metabolic studies including cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism.

Detailed chapters address drug-drug interactions via the assessment of reactive metabolites and drug transporters.

Included assays cover absorption, permeability, plasma binding, and formulation processes.

The book provides guidance on genotoxicity as well as chemical and photo-mutagenicity assays.

Each chapter includes topic introductions and lists of necessary materials for research applications.

Product Specifications

Brand
Humana
Format
paperback
Domain
Amazon UK
Release Date
23 August 2016
Listed Since
11 August 2016

Barcode

No barcode data available

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