£119.11

Humana Cytochrome P450: In Vitro Methods and Protocols Book

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Description

This specialized volume from Humana provides a comprehensive collection of experimental protocols for in vitro cytochrome P450 (CYP) assays. These methods are essential for researchers and professionals working to select drug candidates within a drug discovery pipeline. The text covers the major factors that influence drug metabolism, providing technical guidance on CYP expression levels and kinetic parameters for individual enzymes. It also addresses critical aspects such as CYP inhibition, induction, and time-dependent inhibition (TDI). Beyond CYP-specific studies, the book explores CYP stability, non-CYP stability, and UDP-glucuronosyltransferases (UGT) stability. Readers will find detailed information regarding excretion mechanisms and drug-drug interactions (DDI). This resource serves as a practical guide for those needing to navigate the complex requirements of pharmacology and toxicology research.

Key Features

Provides detailed experimental protocols for setting up various in vitro cytochrome P450 (CYP) assays.

Covers essential drug discovery pipeline factors including CYP expression levels and kinetic parameters.

Includes technical guidance on CYP inhibition, induction, and time-dependent inhibition (TDI).

Addresses stability testing for CYP, non-CYP, and UDP-glucuronosyltransferases (UGT).

Offers insights into excretion mechanisms and the study of drug-drug interactions (DDI).

Serves as a specialized resource for pharmacology and toxicology research professionals.

Product Specifications

Brand
Humana
Format
hardcover
Domain
Amazon UK
Release Date
10 July 2021
Listed Since
10 February 2021

Barcode

No barcode data available

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