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Humana Cytochrome P450: In Vitro Methods and Protocols Book

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Description

This specialized volume from the Methods in Pharmacology and Toxicology series provides essential experimental protocols for setting up in vitro cytochrome P450 (CYP) assays. These methods are vital for selecting drug candidates throughout the drug discovery pipeline. The text covers major factors that affect drug metabolism, including CYP expression levels and kinetic parameters for individual enzymes. Readers will find detailed information regarding CYP inhibition and induction, time-dependent inhibition (TDI), and both CYP and non-CYP stability. Additionally, the book addresses UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI). This collection serves as a technical resource for professionals working in pharmacology and toxicology who require precise protocols for metabolic studies.

Key Features

This Humana publication provides detailed experimental protocols for setting up various in vitro cytochrome P450 (CYP) assays.

The text addresses critical factors in drug metabolism such as CYP expression levels and kinetic parameters for individual enzymes.

Detailed coverage includes CYP inhibition, induction, and time-dependent inhibition (TDI) for drug discovery pipelines.

The volume explores stability studies involving CYP, non-CYP, and UDP-glucuronosyltransferases (UGT).

Technical protocols for studying excretion mechanisms and drug-drug interactions (DDI) are included in this collection.

Product Specifications

Brand
Humana
Format
hardcover
Domain
Amazon UK
Release Date
10 July 2021
Listed Since
10 February 2021

Barcode

No barcode data available

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