Integration of Pharmaceutical Discovery and Development: Case Histories: 11 (Pharmaceutical Biotechnology, 11) - Image 1

£179.99

Springer Integration of Pharmaceutical Discovery and Development: Case Histories: 11 (Pharmaceutical Biotechnology, 11)

Name: Integration of Pharmaceutical Discovery and Development: Case Histories: 11 (Pharmaceutical Biotechnology, 11)
Brand: Springer
Price: 179.99 GBP
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Biomedical Engineering

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Description

In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

Product Specifications

Brand: Springer
Format: hardcover
ASIN: 0306457431
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Biomedical Engineering
Domain: Amazon UK
Release Date: 31 August 1998
Listed Since: 06 February 2007

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Springer Integration of Pharmaceutical Discovery and Development: Case Histories: 11 (Pharmaceutical Biotechnology, 11)

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