£141.25

Humana Optimization in Drug Discovery: In Vitro Methods Book

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Description

Optimization in Drug Discovery: In Vitro Methods, Second Edition provides a comprehensive resource for professionals in pharmacology and toxicology. This thoroughly revised and updated text covers a wide spectrum of essential in vitro assays used throughout the drug development process. Readers gain access to detailed information regarding formulation, plasma binding, absorption, and permeability. The book also explores critical metabolic processes, including cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, as well as CYP inhibition and induction. As part of the Methods in Pharmacology and Toxicology series, this edition addresses drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Each chapter is structured to include introductions to specific topics, making it a valuable reference for studying modern laboratory methodologies.

Key Features

Comprehensive coverage of in vitro assays including formulation, plasma binding, absorption, and permeability studies.

Detailed technical information on cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism.

In-depth analysis of CYP inhibition, induction, and drug transporters within the drug discovery process.

Assessment methods for drug-drug interactions through the study of reactive metabolites.

Includes specialized sections on genotoxicity, chemical mutagenicity, and photo-mutagenicity assays.

Part of the professional Methods in Pharmacology and Toxicology series for academic and industry use.

Product Specifications

Brand
Humana
Format
hardcover
Domain
Amazon UK
Release Date
09 November 2013
Listed Since
08 August 2013

Barcode

No barcode data available

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