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Humana Optimization in Drug Discovery: In Vitro Methods - Second Edition

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Description

Optimization in Drug Discovery: In Vitro Methods, Second Edition is a thoroughly revised and updated reference covering the full spectrum of in vitro assays essential to modern drug development. This comprehensive guide presents formulation strategies, plasma binding assessment, absorption and permeability testing, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism analysis, CYP inhibition and induction protocols, drug transporter evaluation, drug-drug interaction assessment via reactive metabolites, genotoxicity testing, and chemical and photo-mutagenicity assays. Part of the Methods in Pharmacology and Toxicology series, each chapter includes topic introductions and detailed methodology to support both experienced researchers and those new to in vitro pharmacological techniques. This edition serves as an essential resource for pharmaceutical scientists, toxicologists, and drug development professionals seeking validated experimental approaches.

Key Features

The Second Edition covers cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism pathways critical to drug development and safety assessment.

In vitro assays address plasma binding, absorption, and permeability testing to predict drug behaviour in biological systems.

Drug-drug interaction protocols evaluate reactive metabolites and assess CYP inhibition and induction risk.

Genotoxicity and chemical and photo-mutagenicity assays provide safety evaluation frameworks for drug candidates.

Methods in Pharmacology and Toxicology series chapters include introductions and material lists to guide practical implementation.

Product Specifications

Brand
Humana
Format
hardcover
Domain
Amazon UK
Release Date
09 November 2013
Listed Since
08 August 2013

Barcode

No barcode data available

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