Elsevier Fundamentals of Advanced Omics Technologies: from Genes to Metabolites (Comprehensive Analytical Chemistry): Volume 63

Fundamentals of Advanced Omics Technologies: From Genes to Metabolites covers the fundamental aspects of the new instrumental and methodological developments in omics technologies, including those related to genomics, transcriptomics, epigenetics, proteomics and metabolomics, as well as other omics approaches such as glycomics, peptidomics and foodomics. The principal applications are presented in the following complementary volume. The chapters discuss in detail omics technologies, DNA microarray analysis, next-generation sequencing technologies, genome-wide analysis of methylation and histone modifications, emerging nanotechniques in proteomics, imaging mass spectrometry in proteomics, recent quantitative proteomics approaches, and advances in high-resolution NMR-based metabolomics, as well as MS-based non-targeted metabolomics and metabolome analysis by CE-MS, global glycomics analyses, foodomics, and high resolution analytical tools for quantitative peptidomics. Key aspects related to chemometrics, bioinformatics, data treatment, data integration and systems biology, deep-sequencing data analysis, statistical approaches for the analysis of microarray data, the integration of transcriptome and metabolome data and computational approaches for visualization and integration of omics data are also covered. Covers the latest advances in instrumentation, experimental design, sample preparation, and data analysis Provides thorough explanations and descriptions of specific omics technologies Describes advanced tools and methodologies for data pretreatment, storage, curation and analysis, as well as data integration Review The first book covering the principles of omics technologies and their main instrumental developments About the Author Carolina Simó is a Tenured Researcher at the National Research Council of Spain (CSIC) in Madrid, she develops her scientific activities in the Laboratory of Foodomics. Her running research lines include: i) Method development using electrophoretic/chromatographic techniques coupled to mass spectrometry for Proteomics and Metabolomics. ii) Food safety assessment, quality control and other features related to food processing, storage, authenticity; iii) Study of the effect of diet on health/disease and the mechanisms of nutrients and bioactive food components at the molecular level. She has published over 50 SCI papers and 10 book chapters. Her h index is 20 and her works have received over 1000 citations (August-2013). Dr. Alejandro Cifuentes is a Full Research Professor at the National Research Council of Spain (CSIC) in Madrid and Head of the Laboratory of Foodomics. He has been Director of the Institute of Food Science Research and Deputy Director of the Institute of Industrial Fermentations, both belonging to CSIC. Currently he is Director of the Metabolomics Platform belonging to the International Excellence Campus UAM+CSIC. Alejandro's activity includes the development of advanced analytical methods (e.g., metabolomics, transcriptomics, proteomics) for foodomics, food quality and safety, as well as extraction and characterization of bioactive compounds from natural sources and their effect on human health. He holds different national and international awards, is member of the Editorial Board of 11 international journals (including J. Chromatogr. A, J. Pharmaceut. Biomed., J. Sep. Sci., Food Anal. Method., Int. J. Mol. Sci.) and Editor of TrAC-Trends in Analytical Chemistry, Electrophoresis and Current Opinion in Food Science (Foodomics Section). He has published more than 230 SCI papers, 20 books and book chapters and 8 patents. His h index is 56 (February 2016) and his works have received more than 10000 citations. Alejandro has given more than 150 invited lectures in different national and international meetings in Europe, Asia, Africa, America and Oceania. He has defined for the first time in a SCI journal the new discipline of Foodom