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OmniScriptum Les Maladies Autoimmunes Thyroïdiennes: Caractérisation d'un auto-épitope B immunodominant de la thyroperoxydase et obtention de mimes peptidiques d'intérêt biomédical (Omn.Univ.Europ.)

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Description

Les autoanticorps (aAc) anti-thyroperoxydase (TPO) constituent l'un des principaux biomarqueurs des maladies autoimmunes thyroïdiennes (MAIT). Ils sont présents en forte concentration dans chez patients atteints de MAIT et reconnaissent une région immunodominante (RID) sur la TPO. Ces aAc présentent également un potentiel destructeur pour la thryoïde. Malgré les connaissances accumulées au cours de nombreuses années de recherche plusieurs questions sur la nature et le rôle de ces aAc anti-TPO restaient en suspens. Les travaux présentés dans ce livre tentent d'apporter quelques réponses à ces questions et s'articule selon trois axes: (1) Évaluer l'importance des aAcs anti-TPO de chaînes légères lambda dans les MAIT. (2) Délimiter de façon plus précise sur un modèle tridimensionnel de la TPO la RID reconnue par ces aAc anti-TPO. (3) Utiliser les informations obtenues dans les points 1 et 2 afin d'inventer des leurres peptidiques pour détourner les aAcs anti-TPO de leur cible in vivo et diminuer leurs effets toxiques au cours des MAIT. Les résultats de ce travail a fait l'objet d'une soutenance de thèse de Doctorat a l'Université Montpellier I.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
28 May 2010
Listed Since
01 June 2010

Barcode

No barcode data available

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