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ÉDITIONS UNIVERSITAIRES EUROPÉENNES Endocrinopathie extrathyroidienne hypothyroïdienne

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Description

L'insuffisance surrénalienne deutéropathique latente est source éventuelle de lassitude extrême et de moindre résistance aux infections et au stress, elle se caractérise cependant par une cortisolémie normale qui plus est, garde son rythme circadien. Le taux des 17 corticostéroïdes urinaires est abaissé et à un moindre degré celui des 17 hydroxystéroïdes et se normalisaient après stimulation par le Tétracosactide. En fait, le taux de production du cortisol n'est pas différent de celui des témoins, mais la demi-vie du cortisol est allongée et sa clearance métabolique sensiblement diminué bien que réversible sous traitement substitutif thyroïdien. Ces modifications du métabolisme périphérique du cortisol sont la conséquence du ralentissement des activités enzymatiques hépatiques (notamment de la 5 alpha réductase et de la 11 bêta hydroxystéroïde déshydrogénase) sous l'effet de l'hypothyroïdie.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
11 December 2019
Listed Since
27 February 2020

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