Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release - Image 1

£47.00

LAP Lambert Academic Publishing Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release

Name: Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release
Brand: LAP Lambert Academic Publishing
Price: 47.0 GBP
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Pharmacology

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Description

The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659453358
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 29 September 2013
Listed Since: 24 October 2013

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LAP Lambert Academic Publishing Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release

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