Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment - Image 1

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LAP Lambert Academic Publishing Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment

Name: Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment
Brand: LAP Lambert Academic Publishing
Price: 49.0 GBP
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Pharmacology

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Description

Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms of dissolution rate, drug release and solubility.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3848419505
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 14 March 2012
Listed Since: 13 March 2012

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LAP Lambert Academic Publishing Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment

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