Comprative Study on Effect of Natural & Synthetic Superdisintegrants: Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants - Image 1

£48.00

LAP Lambert Academic Publishing Comprative Study on Effect of Natural & Synthetic Superdisintegrants: Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants

Name: Comprative Study on Effect of Natural & Synthetic Superdisintegrants: Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants
Brand: LAP Lambert Academic Publishing
Price: 48.0 GBP
Availability: InStock

Pharmacology

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Description

The study was undertaken with an aim to formulate Mouth Dissolving tablets of Diclofenac Sodium containing Fenugreek and SSG as natural and artificial superdisintegrant respectively and to compare its release profile with the same. Granules were evaluated for tests, bulk density, tapped density, compressibility index and hausner ratio before using punched as tablets. In vitro dissolution test are found for 6 batches. From these results AF6 was selected as optimized formulation. All the formulation shows the good blend properties for direct compression and hence tablets were prepared by using direct compression technology. This rapid disintegration of the FDTs was due to the penetration of saliva into the pores of the tablet, which lead to the swelling of superdisintegrant to create enough hydrodynamic pressure for quick and complete disintegration of the tablet. Fenugreek was effective. Hence it can be concluded that instead of using artificial superdisintegrant, we use should natural because they give better dissolution profile, are cheaper, abundantly available, non toxic and non-irritating in nature.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659315729
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 29 December 2012
Listed Since: 09 January 2013

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LAP Lambert Academic Publishing Comprative Study on Effect of Natural & Synthetic Superdisintegrants: Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants

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