£49.00

LAP Lambert Academic Publishing Ambroxol HCl SR Tablet: Formulation Development and Evaluation

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Last 630 days • 630 data points (No recent data available)

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£49.00 £45.54 £46.29 £47.05 £47.80 £48.56 £49.32 16 June 2024 20 November 2024 26 April 2025 30 September 2025 07 March 2026

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29 days 138 days 463 days · current 0 116 232 347 463 £46 £47 £49 Days at Price

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Most common price: £49 (463 days, 73.5%)

Price range: £46 - £49

Price levels: 3 different prices over 630 days

Description

The purpose of the present investigation was to design and evaluate sustained release tablets of a sparingly water soluble drug Ambroxol Hydrochloride, two hydrophilic polymers METHOCEL K15MCR and METHOCEL K100MCR and hydrophobic Eudragit RL100 were used in tablets prepared by direct compression. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content. The tablets were subjected to various tests for physical parameters such as thickness, hardness and friability, and in vitro release studies. The in vitro dissolution study was carried out for 12 hours using United States Pharmacopoeia (USP) paddle-type dissolution apparatus (Apparatus 2) in phosphate buffer (pH 6.8). The results of dissolution studies indicated that formulations containing Methocel K100 MCR showed better dissolution properties compared to formulaitons containing Methocel K15 MCR.It was found that Hydrophilic polymers showed better released profile than the hydrophobic polymers.

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