Springer Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface: 25 (AAPS Advances in the Pharmaceutical Sciences Series, 25)

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies―this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields. From the Back Cover Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies―this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields. About the Author Shobha N. Bhattachar is a Director in Small Molecule Design and Development at Eli Lilly and Company. She has a Bachelor’s degree in Pharmacy from Bangalore University, India, and a Master’s degree in Pharmaceutical chemistry from the University of Kansas. Prior to joining Lilly, Bhattachar worked for eight years at Pfizer in Ann Arbor MI, in the Research Formulations group. She has authored/co-authored 15 publications covering wide ranging topics in the field of Pharmaceutical Sciences. Her current interests include the discovery-development interface, clinical candidate selection and developability assessment, clinical formulation development and biopharmaceutical aspects of drug product design. John S. Morrison earned his doctorate in physical organic chemistry from the University of Western Ontario studying the photochemical mechanisms responsible for the light-struck reaction in beer.  After graduation John joined the Preformulation and Analytical Method Development group of Apotex Inc evaluating drug substances and novel drug product formulations.  He then transitioned to the Discovery Pharmaceutics group of Bristol-Myers Squibb characterizing early drug candidates and establishing delivery strategies for a variety of dosing routes and molecular modalities.  His current role bridges the discovery/development divide, collaboratively supporting multi-disciplinary discovery teams as well as determining and mitigating developability risks for potential clinical drug candidates.  John has also led several AAPS committees and co-organizes the ACS Drug Design and Delivery webinar series. David M. Bender is  a Senior Research Scientist in Small Molecule Design and Development at Eli Lilly