Academic Press The Design and Development of Novel Drugs and Vaccines: Principles and Protocols

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Review "I have read other books on clinical research, but none with the level of detail and particular focus on drug design (the computational drug design sections) that this one has. This book is very detailed-oriented from that standpoint, and it can certainly serve as a useful tool for those developing vaccines." --© Doody’s Review Service, 2021, Patrick J Scoble, PharmD(PJS Pharma Consulting LLC), reviewer, expert opinion Review A comprehensive accounting of drug and vaccine development methods and protocols that covers both in silico and experimental techniques From the Back Cover Vaccine and drug development has proven massively important for combating infectious disease. Despite huge success, a critical need nevertheless remans for new and effective vaccines and drugs. In turn, accelerating growth in bioinformatic techniques and applications, and large amounts of experimental data, have transformed the vaccine and drug development landscape. Consequently, there is a need for a holistic overview of both the in silico and experimental methods and protocols needed to develop drug and vaccine candidates. Design and Development of Novel Vaccines presents both in silico methods and experimental protocols for vaccine and drug design and development in a single volume, critically reviewing the most current research, giving emphasis to approaches and technologies that accelerate and lower the cost of product development. Consisting in three parts, the book first reviews the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, using bioinformatics; second, it covers several molecular methods for in vitro studies of the desired target; third, it presents various physiological parameters for in vivo studies. The book includes an overview of preclinical trials and clinical research, and information on FDA approval. This title presents, in a single holistic volume, essential knowledge and solutions for those working on novel vaccine and drug design. About the Author Tarun Kumar Bhatt is an Assistant Professor in the Department of Biotechnology, at the Central University of Rajasthan, India. He received his PhD from the International Centre for Genetic Engineering and Biotechnology, New Delhi and gained post-doctoral experience at the Scripps Research Institute in San Diego, California. He has published over 25 articles and has extensive experience researching drug and vaccine development. Surendra Nimesh, UGC Assistant Professor at Central University of Rajasthan, Rajasthan, India. Surendra received his M.S. in Biomedical Science from the Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi. He completed his PhD. In Nanotechnology at the Institute of Genomics and Integrative Biology (CSIR), Delhi. After completing his postdoctoral studies at the Ecole Polyetchnique of Montreal, Surendra joined the Clinical Research Institute of Montreal (IRCM), Canada as Postdoctoral Fellow. After completing his commitment at IRCM, he joined McGill University for short time. He also worked as NSERC visiting fellow at Health Canada, Canada. His research interests include nanoparticles-mediated gene,