Adis Efflux-Mediated Antimicrobial Resistance in Bacteria: Mechanisms, Regulation and Clinical Implications

This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants. Review “This extraordinarily comprehensive book covers the efflux pumps of several important bacterial genera regarding types of pumps, regulation of the pumps, and contribution of the pumps to antibiotic resistance. … audience includes anyone in the scientific field of antibiotic resistance. … appropriate for students and seasoned researchers. Infectious disease physicians also may find it helpful with respect to mechanisms of resistance and antibiotic stewardship. … I am not aware of a more comprehensive book on efflux‐mediated resistance than this one.” (Nancy D. Hanson, Doody's Book Reviews, February, 2017) From the Back Cover This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae,  Acinetobacter,  Neisseria,  Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants. About the Author XIAN-ZHI LI, M.D., Ph.D., is a Team Leader at the Veterinary Drugs Directorate of Health Canada for regulation of drug products, dealing with microbiological and toxicological safety assessments of drugs as well as antimicrobial drug policy. Dr. Li received his medical degree and a M.Sc. in Pharmacology, respectively, from Luzhou Medical College and West China University of Medical Sciences (WCUMS [now Sichuan University]; with Dr. Yu-Sheng Wang) in China in the 1980s, followed by a faculty appointment in Pharmacology at WCUMS. He later obtained another M.Sc. and Ph.D. in Microbiology from the University of Saskatchewan (with Dr. Kurt E. Williams) and Queen's University, Kingston (with Dr. Keith Poole) in Canada, respectively. He has been actively involved for over a decade in the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) under the Public Health A