Springer Cancer Genetics: 155 (Cancer Treatment and Research, 155)

This is a collection of chapters covering the key recent developments in cancer genetics which have an impact on clinical care. The target audience is physicians and scientists who need to be apprised on the most recent developments in the field. Review From the reviews: “This is a slim, handy book with 5 chapters of 112 pages, including the index. … appeal to a broad audience, whether expert or generalist, trainee or experienced … Cancer Genetics provides the fundamental principles of evidence-based translational human genetics as well as the basic knowledge to judge for oneself the who, what, when, where, why, and how of cancer genetics and genomics as relevant to clinical practice.” (Charis Eng, Journal of the American Medical Association, June, 2011) “Provides comprehensive information on several selected topics … covered by recent cancer genetics field. … highly recommended to all with interest in the genetic components of cancer, mainly those of breast, gastric and colorectal, as well as pediatric cancers. … frame of specific cancer type may be interesting also for more broad range of readers. … The outline of challenges in understanding how … acquired somatic alterations in the tumor genome interact to exact phenotypic differences in cancer makes reading of this tiny book exciting.” (Z. Bartosova, Neoplasma, March, 2011) From the Back Cover Cancer genetics has revolutionized the practice of medicine as inherited genetic information helps predicts which individuals are at risk of developing various forms of cancer. Furthermore, somatically acquired genetic changes help identify therapeutic targets for patients with several common tumor types such as breast and colon cancer. Cancer Genetics reviews seminal discoveries such as genetic susceptibility to gastric cancer, ethical issues related to cancer genetics, the role of common variants in the development of breast cancer, novel genetic findings related to neuroblastoma, and the role of constitutively decreased TGF-beta signaling, which is emerging as one of the most common causes of colorectal cancer. The book has been written for all clinicians and researchers interested in cancer genetics, including oncologists, genetic counselors and cancer researchers both in academia and in industry. "Genetic alterations are a fundamental component of all cancers. This text highlights critical issues relevant for both basic scientists and clinicians. Recognized thought leaders in the field discuss current knowledge and future challenges." - Steven T. Rosen, M.D., Series Editor