Academic Press Clinical Genome Sequencing: Psychological Considerations

Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing, genome sequencing in pediatrics, genome sequencing in prenatal testing, and ethical issues in genome sequencing. Applied clinical case studies support concept illustration, making this an invaluable, practical reference for this important and multifaceted topic area within genomic medicine. Review Thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, with an emphasis on maximizing genomic technology About the Author Dr. Aad Tibben is Professor and Chair of Psychology of Clinical Genetics at the Leiden University Medical Center, Leiden, the Netherlands, as well as Visiting Professor in the Social and Behavioral Branch of the National Institutes of Health, Bethesda, MD. At Leiden University Medical Center Dr. Tibben served as Project Leader of the research line on psychological effects of predictive DNA-testing for late onset hereditary disorders, Co-chair of the Genetic Testing Working Group, Lead-facilitator of the Psychological Interventions Working Group of the European Huntington's Disease Network Course, and Director of the Basic and Advanced Genetic Counseling Course. Additionally, Dr. Tibben has published more than 170 papers in peer reviewed journals including the European Journal of Human Genetics, the Journal of Genetic Counseling, and Clinical Genetics. Dr. Barbara B. Biesecker serves as Head of the National Human Genome Research Institute’s (NHGRI) Genetic Services unit and is Director of the Genetic Counselor Training Program at NHGRI. Previously, Dr. Biesecker has served in several academic positions, including at the University of Wisconsin and the University of Michigan. At the University of Michigan, she and colleagues counseled the first extended family identified with a BRCA1 mutation by linkage analysis. Additionally, Dr. Biesecker has been instrumental in fostering social and behavioral research in collaboration with the NHGRI ClinSeq® cohort. Among the awards Dr. Biesecker has received are the inaugural Diane Baker Alumnae Lecture Award from the University of Michigan, and NIH Director's awards for mentoring and for the Katrina Missing Persons Effort. She served as president of the National Society of Genetic Counselors in 1989, and has recently held several task force positions in the society. Dr. Biesecker has published more than 110 papers in peer reviewed journals including Genetics in Medicine, Patient Education and Counseling, and the Journal of Genetic Counseling.