Humana The Molecular Basis of Human Cancer

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction. Review "The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies....The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced....the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." - Annals of Oncology "This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." -Quarterly Review of Biology From the Back Cover Molecular biology holds great promise for the development of new strategies for cancer prevention and treatment. In The Molecular Basis of Human Cancer, internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms of cancer induction. They also consider the future directions of research, including discussions of the exploitation of molecular targets for developing anticancer drugs, recent developments in gene therapy, and the appropriate use of molecular information in genetic counseling. Up-to-date and forward-looking, The Molecular Basis of Human Cancer offers a critically integrated survey of the full range of state-of-the-art cancer molecular biology and genetics and constitutes indispensable reading for all cancer researchers today.