£103.00

Wiley Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists

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£111.80 £99.82 £102.43 £105.05 £107.66 £110.28 £112.89 09 June 2024 14 November 2024 21 April 2025 26 September 2025 04 March 2026

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116 days 191 days · current 49 days 21 days 5 days 252 days 0 63 126 189 252 £101 £103 £104 £105 £108 £112 Days at Price

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Most common price: £112 (252 days, 39.7%)

Price range: £101 - £112

Price levels: 6 different prices over 634 days

Description

Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields from pharmacology to medicinal chemistry to biophysics to clinical medicine.

Product Specifications

Brand
Wiley
Format
Hardcover
Domain
Amazon UK
Release Date
16 April 2013
Listed Since
02 October 2012

Barcode

No barcode data available

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