Wiley Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples

This comprehensive resource covers the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. It presents the principles of lipid absorption and covers formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs. From the Inside Flap The principles and formulation of lipid-based drug delivery systems With its promise for improving drug absorption, the emerging field of lipid-based drug delivery systems has attracted considerable attention from academia to industry. Filling the need for a standard text on the subject, this book assembles a group of experienced investigators and educators from the front line of pharmaceutical sciences to provide a comprehensive resource on the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. Presenting a solid grounding in the fundamental principles of lipid absorption in the intestines and vascular body systems, the text gives readers in-depth insight into the formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs. Chapters cover: Interaction of drug transporters with excipients Formulation issues around lipid-based oral and parenteral delivery systems Biological implications of lipid-based parenteral drug delivery systems Principles in the development of intravenous lipid emulsions Protein adsorption patterns on parenteral lipid formulationsa key factor determining the in vivo fate Nanoparticle targeting for drug delivery across the blood-brain barrier Lipid-coated perfluorocarbon nanostructures as parenteral therapeutic agents From the Back Cover The principles and formulation of lipid-based drug delivery systems With its promise for improving drug absorption, the emerging field of lipid-based drug delivery systems has attracted considerable attention from academia to industry. Filling the need for a standard text on the subject, this book assembles a group of experienced investigators and educators from the front line of pharmaceutical sciences to provide a comprehensive resource on the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. Presenting a solid grounding in the fundamental principles of lipid absorption in the intestines and vascular body systems, the text gives readers in-depth insight into the formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs. Chapters cover: Interaction of drug transporters with excipients Formulation issues around lipid-based oral and parenteral delivery systems Biological implications of lipid-based parenteral drug delivery systems Principles in the development of intravenous lipid emulsions Protein adsorption patterns on parenteral lipid formulationsa key factor determining the in vivo fate Nanoparticle targeting for drug delivery across the blood-brain barrier Lipid-coated perfluorocarbon nanostructures as parenteral therapeutic agents About the Author KISHOR M. WASAN, PhD, is a Professor and Distinguished University Scholar at The University of British Columbia Faculty of Pharmaceutical Sciences. He is the Chairman of the AAPS Focus Group in Parenteral Lipid-Based Drug Delivery Systems. His research has earned him over $10 million in grants and funding, and he has written over 290 peer-reviewed publications and abstracts. In addition,