Elsevier Recent Advances in Parkinsons Disease: Part I: Basic Research (Progress in Brain Research): Volume 183

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist Review Presents Parkinson’s disease as a topic for basic, translational, and clinical investigation From the Back Cover This issue of Progress in Brain Research is split over two volumes and captures all the richness and complexity of Parkinsons Disease as a topic for basic, translational, and clinical investigation. This first volume, Part I: Basic Research, starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration (Section I: Genetic and molecular mechanisms of neurodegeneration in PD). This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods (Section II: Cellular and system-level pathophysiology of the basal ganglia in PD). The second volume, Part II: Translational and Clinical Research, follows on from this with sections entitled Animal models of PD, Exploring PD with brain imaging and Frontiers in PD treatment.| This issue of Progress in Brain Research is split over two volumes and captures all the richness and complexity of Parkinsons Disease as a topic for basic, translational, and clinical investigation. This first volume, Part I: Basic Research, starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration (Section I: Genetic and molecular mechanisms of neurodegeneration in PD). This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods (Section II: Cellular and system-level pathophysiology of the basal ganglia in PD). The second volume, Part II: Translational and Clinical Research, follows on from this with sections entitled Animal models of PD, Exploring PD with brain imaging and Frontiers in PD treatment. About the Author As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients