Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease: 517 (Advances in Experimental Medicine and Biology, 517) - Image 1

£59.97

Springer Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease: 517 (Advances in Experimental Medicine and Biology, 517)

Name: Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease: 517 (Advances in Experimental Medicine and Biology, 517)
Brand: Springer
Price: 63.54 GBP
Availability: InStock

Children's Books

Price History & Forecast

Last 44 days • 44 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 44 days • 5 price levels

Days at Price

Current Price

Price Analysis

Most common price: £65 (13 days, 29.5%)

Price range: £56 - £65

Price levels: 5 different prices over 44 days

Description

Parkinson's disease, a degenerative brain disorder, affects an estimated 0.25-0.50% of the population. Symptoms result from neuronal degeneration in the nigrostriatal dopaminergic pathway and include tremor, rigidity and gradual slow ness of spontaneous movement. The cause of Parkinson's disease is only partially understood; both environmental factors and a genetic predisposition have been im plicated in its etiopathogenesis. Neural transplantation is being used experimentally for providing an alternative biological source of dopamine both in animal studies and in experimental clinical trials. This book is the result of 15 years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse, a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. The weaver mouse constitutes the only available laboratory model with a chronic progressive disease that mimics Parkinsonism. The other two models currently used to investigate dopaminergic mechanisms rely on the use of the neurotoxins- hydroxydopamine and methylphenyltetrahydropyridine for the selective removal of dopaminergic neurons from an otherwise healthy organism. Structural and functional aspects of transplantation of mesencephalic dopamin ergic grafts into the striatum of weaver mice are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor neuron survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopam ine uptake function and receptor binding, gene expression of several structural and neurotransmitter-receptor related molecules, the levels of striatal amino acid receptors, and the behavioral effects of unilateral and bilateral neuronal transplantations.

Product Specifications

Brand: Springer
Format: Hardcover
ASIN: 0306474352
Category: Books > Subjects > Children's Books
Domain: Amazon UK
Release Date: 31 January 2003
Listed Since: 07 February 2007

Barcode

No barcode data available

Springer Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease: 517 (Advances in Experimental Medicine and Biology, 517)

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Cell Transplantation for Neurological Disorders: Toward Reconstruction of the Human Central Nervous System (Contemporary Neuroscience)

Neurobiology of DOPA as a Neurotransmitter

Recent Advances in Parkinsons Disease: Part I: Basic Research (Progress in Brain Research): Volume 183

Recent Advances in Parkinson's Disease (Volume 252) (Progress in Brain Research, Volume 252)

Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease

The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity: 199 (Advances in Anatomy, Embryology and Cell Biology, 199)

Neural Stem Cells In Health And Disease

Springer - Deep Brain Stimulation for Neurological Disorders

Restorative Therapies in Parkinson's Disease

Excitotoxicity in Neurological Diseases: New Therapeutic Challenge

Cortico-Subcortical Dynamics in Parkinson’s Disease (Contemporary Neuroscience)

Springer - Mitochondrial Mechanisms in Parkinson's Disease

The Subthalamic Nucleus: Part I: Development, Cytology, Topography and Connections: 198 (Advances in Anatomy, Embryology and Cell Biology, 198)

Neurodegeneration: Methods and Protocols: 793 (Methods in Molecular Biology, 793)

Inflammation in Parkinson's Disease: Scientific and Clinical Aspects

Neurochemistry: Molecular and Cellular Clinical Applications

The Neuroscience of Parkinson's Disease

Neuroglia in Neurodegenerative Diseases: 1175 (Advances in Experimental Medicine and Biology, 1175)

Functional Neural Transplantation IV: Translation to Clinical Application, Part A (Volume 230) (Progress in Brain Research, Volume 230)

Neurotoxic Factors in Parkinson’s Disease and Related Disorders

Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic (Contemporary Neuroscience)

Humana Dopamine: Methods and Protocols: 964 (Methods in Molecular Biology)

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors