The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity: 199 (Advances in Anatomy, Embryology and Cell Biology, 199) - Image 1

£72.95

Springer The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity: 199 (Advances in Anatomy, Embryology and Cell Biology, 199)

Name: The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity: 199 (Advances in Anatomy, Embryology and Cell Biology, 199)
Brand: Springer
Price: 72.95 GBP
Availability: InStock

Neurology & Clinical Neurophysiology

New to our records — first sighting 24 days ago. We'll learn its rhythm.

24 days of data · current price £73

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 9 days · 9 data points (no recent data)

Historical

Generating forecast…

Price Distribution

Price distribution over 9 days • 2 price levels

Days at Price

Current Price

Price Analysis

Most common price: £75 (8 days, 88.9%)

Price range: £73 - £75

Price levels: 2 different prices over 9 days

Description

Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared. From the Back Cover This monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3540794611
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Neurology & Clinical Neurophysiology
Domain: Amazon UK
Release Date: 23 July 2008
Listed Since: 22 April 2008

Barcode

No barcode data available

Springer The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity: 199 (Advances in Anatomy, Embryology and Cell Biology, 199)

New to our records — first sighting 24 days ago. We'll learn its rhythm.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

The Subthalamic Nucleus: Part I: Development, Cytology, Topography and Connections: 198 (Advances in Anatomy, Embryology and Cell Biology, 198)

Cortico-Subcortical Dynamics in Parkinson’s Disease (Contemporary Neuroscience)

Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models

Cortico-Subcortical Dynamics in Parkinson’s Disease (Contemporary Neuroscience)

Brain Stimulation: Handbook of Clinical Neurology: Volume 116

Neurotoxic Factors in Parkinson’s Disease and Related Disorders

Neurobiology of DOPA as a Neurotransmitter

Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease: 517 (Advances in Experimental Medicine and Biology, 517)

Emerging Horizons in Neuromodulation: New Frontiers in Brain and Spine Stimulation (Volume 159) (International Review of Neurobiology, Volume 159)

Academic Press - Nonlinear Dynamics of Parkinson's Disease

Parkinson's Disease and Movement Disorders

Parkinson's Disease: Molecular and Therapeutic Insights From Model Systems

Stereotaxis in Parkinson Syndrome: Clinical-Anatomical Contributions to Its Pathophysiology

Functional Neural Transplantation IV: Translation to Clinical Application, Part A (Volume 230) (Progress in Brain Research, Volume 230)

The Neuroscience of Everyday Life: An Applied Guide for Health Sciences Students

Sigma Receptors: Their Role in Disease and as Therapeutic Targets: 964 (Advances in Experimental Medicine and Biology, 964)

Functional Neural Transplantation III (Progress in Brain Research): Primary and Stem Cell Therapies for Brain Repair, Part II: Volume 201 (Progress in Brain Research, Volume 201)

Horizons in Neuroscience Research: Volume 37

Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease (Volume 2) (International Review of Movement Disorders, Volume 2)

Restorative Therapies in Parkinson's Disease

Forebrain Atlas of the Short-tailed Fruit Bat, Carollia perspicillata: Prepared by the Methods of Nissl and NeuN Immunohistochemistry

Advances in Neuropharmacology: Drugs and Therapeutics

Macro Roles for MicroRNAs in the Life and Death of Neurons (Research and Perspectives in Neurosciences)

Clinical Aspects of Sensory Motor Integration: 4 (Advances in Applied Neurological Sciences, 4)