Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials: Handbooks of Modern Statistical Methods (Chapman & Hall/CRC Handbooks of Modern Statistical Methods) - Image 1

£60.39

CRC Press Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials: Handbooks of Modern Statistical Methods (Chapman & Hall/CRC Handbooks of Modern Statistical Methods)

Name: Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials: Handbooks of Modern Statistical Methods (Chapman & Hall/CRC Handbooks of Modern Statistical Methods)
Brand: CRC Press
Price: 60.39 GBP
Availability: InStock

Public Health

This is the usual price. Wait for it to drop, or tell us your number.

£60 today · usual range £0–£0 · best ever £53

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 513 days • 513 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 513 days • 5 price ranges

Days at Price

Current Price

Price Analysis

Most common range: £56-60 (221 days, 43.1%)

Price range: £53 - £72

Price levels: 5 price ranges over 513 days

Description

Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials gives a thorough presentation of state-of-the-art methods for early phase clinical trials. The methodology of clinical trials has advanced greatly over the last 20 years and, arguably, nowhere greater than that of early phase studies. The need to accelerate drug development in a rapidly evolving context of targeted therapies, immunotherapy, combination treatments and complex group structures has provided the stimulus to these advances. Typically, we deal with very small samples, sequential methods that need to be efficient, while, at the same time adhering to ethical principles due to the involvement of human subjects. Statistical inference is difficult since the standard techniques of maximum likelihood do not usually apply as a result of model misspecification and parameter estimates lying on the boundary of the parameter space. Bayesian methods play an important part in overcoming these difficulties, but nonetheless, require special consideration in this particular context. The purpose of this handbook is to provide an expanded summary of the field as it stands and also, through discussion, provide insights into the thinking of leaders in the field as to the potential developments of the years ahead. With this goal in mind we present: An introduction to the field for graduate students and novices A basis for more established researchers from which to build A collection of material for an advanced course in early phase clinical trials A comprehensive guide to available methodology for practicing statisticians on the design and analysis of dose-finding experiments An extensive guide for the multiple comparison and modeling (MCP-Mod) dose-finding approach, adaptive two-stage designs for dose finding, as well as dose–time–response models and multiple testing in the context of confirmatory dose-finding studies. John O’Quigley is a professor of mathematics and research director at the French National Institute for Health and Medical Research based at the Faculty of Mathematics, University Pierre and Marie Curie in Paris, France. He is author of Proportional Hazards Regression and has published extensively in the field of dose finding. Alexia Iasonos is an associate attending biostatistician at the Memorial Sloan Kettering Cancer Center in New York. She has over one hundred publications in the leading statistical and clinical journals on the methodology and design of early phase clinical trials. Dr. Iasonos has wide experience in the actual implementation of model based early phase trials and has given courses in scientific meetings internationally. Björn Bornkamp is a statistical methodologist at Novartis in Basel, Switzerland, researching and implementing dose-finding designs in Phase II clinical trials. He is one of the co-developers of the MCP-Mod methodology for dose finding and main author of the DoseFinding R package. He has published numerous papers on dose finding, nonlinear models and Bayesian statistics, and in 2013 won the Royal Statistical Society award for statistical excellence in the pharmaceutical industry.

Product Specifications

Brand: CRC Press
Format: Paperback
ASIN: 0367330687
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues > Public Health
Domain: Amazon UK
Release Date: 08 August 2019
Listed Since: 21 March 2019

Barcode

No barcode data available

CRC Press Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials: Handbooks of Modern Statistical Methods (Chapman & Hall/CRC Handbooks of Modern Statistical Methods)

This is the usual price. Wait for it to drop, or tell us your number.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials: Handbooks of Modern Statistical Methods (Chapman & Hall/CRC Handbooks of Modern Statistical Methods)

Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesia: Classical, Adaptive, and Bayesian Methods

Bayesian Analysis with R for Drug Development: Concepts, Algorithms, and Case Studies (Chapman & Hall/CRC Biostatistics Series)

Bayesian Analysis with R for Drug Development: Concepts, Algorithms, and Case Studies (Chapman & Hall/CRC Biostatistics Series)

Statistical Methods for Dose-Finding Experiments: 24 (Statistics in Practice)

Statistical Methods in Drug Combination Studies: 69 (Chapman & Hall/CRC Biostatistics Series)

Bayesian Methods and Ethics in a Clinical Trial Design: 214 (Wiley Series in Probability and Statistics)

Model-Assisted Bayesian Designs for Dose Finding and Optimization: Methods and Applications (Chapman & Hall/CRC Biostatistics Series)

CRC Press Bayesian Methods in Pharmaceutical Research Book

Bayesian Methods in Pharmaceutical Research (Chapman & Hall/CRC Biostatistics Series)

Exposure-Response Modeling: Methods and Practical Implementation (Chapman & Hall/CRC Biostatistics Series)

Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting: 67 (Chapman & Hall/CRC Biostatistics Series)

Sample Size Calculations in Clinical Research (Chapman & Hall/CRC Biostatistics Series)

Bayesian Precision Medicine (Chapman & Hall/CRC Biostatistics Series)

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

Adaptive Design Theory and Implementation Using SAS and R (Chapman & Hall/CRC Biostatistics Series)

Adaptive Design Theory and Implementation Using SAS and R (Chapman & Hall/CRC Biostatistics Series)

Statistical Methods in Healthcare

Biosimilar Clinical Development: Scientific Considerations and New Methodologies (Chapman & Hall/CRC Biostatistics Series)

Multiple Testing Problems in Pharmaceutical Statistics (Chapman & Hall/CRC Biostatistics Series)

Cross-over Trials in Clinical Research: 5 (Statistics in Practice)

Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting (Chapman & Hall/CRC Biostatistics Series)

Clinical Trial Biostatistics and Biopharmaceutical Applications

Statistical Remedies for Medical Researchers (Springer Series in Pharmaceutical Statistics)