Bayesian Designs for Phase I-II Clinical Trials: 92 (Chapman & Hall/CRC Biostatistics Series) - Image 1

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CRC Press Bayesian Designs for Phase I-II Clinical Trials: 92 (Chapman & Hall/CRC Biostatistics Series)

Name: Bayesian Designs for Phase I-II Clinical Trials: 92 (Chapman & Hall/CRC Biostatistics Series)
Brand: CRC Press
Price: 96.99 GBP
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Description

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

Product Specifications

Brand: CRC Press
Format: hardcover
ASIN: 1498709559
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine
Domain: Amazon UK
Release Date: 27 June 2016
Listed Since: 23 January 2016

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CRC Press Bayesian Designs for Phase I-II Clinical Trials: 92 (Chapman & Hall/CRC Biostatistics Series)

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