Humana - Targeting the DNA Damage Response for Anti-Cancer Therapy

Explore the evolving role of the DNA damage response (DDR) in tumorigenesis with this specialized text from the Cancer Drug Discovery and Development series. As research advances, it has become clear that a proficient DDR can lead to cellular resistance against standard-of-care DNA damaging drugs and ionizing radiation (IR) used across many cancer types. This book examines how defects in this network, particularly within the ATM mediated signaling pathway, are frequently observed in various cancers. These defects can create a genomically unstable environment that allows mutations to persist. By understanding these mechanisms, researchers and medical professionals can better grasp the complexities of cancer development and the potential for new therapeutic approaches. This resource provides essential insights for those studying oncology and the mechanisms behind drug resistance in cancer treatment.