£147.11

Humana - Targeting the DNA Damage Response for Anti-Cancer Therapy

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£147.11 £145.19 £145.61 £146.03 £146.45 £146.87 £147.29 16 March 2026 27 March 2026 07 April 2026 18 April 2026 29 April 2026

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Price levels: 2 different prices over 45 days

Description

Explore the evolving role of the DNA damage response (DDR) in tumorigenesis with this specialized text from the Cancer Drug Discovery and Development series. As research advances, it has become clear that a proficient DDR can lead to cellular resistance against standard-of-care DNA damaging drugs and ionizing radiation (IR) used across many cancer types. This book examines how defects in this network, particularly within the ATM mediated signaling pathway, are frequently observed in various cancers. These defects can create a genomically unstable environment that allows mutations to persist. By understanding these mechanisms, researchers and medical professionals can better grasp the complexities of cancer development and the potential for new therapeutic approaches. This resource provides essential insights for those studying oncology and the mechanisms behind drug resistance in cancer treatment.

Key Features

Examines the role of DNA damage response (DDR) in the development of tumors.

Analyzes how proficient DDR contributes to cellular resistance against standard-of-care DNA damaging drugs.

Provides detailed information on the impact of ionizing radiation (IR) on cancer cells.

Covers defects in the ATM mediated signaling pathway and their presence in various cancers.

Discusses how genomic instability and persistent mutations occur during tumorigenesis.

Product Specifications

Brand
Humana
Format
paperback
Domain
Amazon UK
Release Date
21 December 2018
Listed Since
20 December 2018

Barcode

No barcode data available

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