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Springer Platinum and Metal Coordination Compounds Book

Amazon

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Description

This scientific text from Springer examines the role of platinum and other metal coordination compounds in cancer chemotherapy. The research focuses on how DNA excision repair influences tumor cell resistance to platinum compounds. It details how inhibiting this repair system through combination chemotherapy with excision repair inhibitors like HU and Ara-C can produce synergistic cell kills. The content explores the increased levels and persistence of DNA interstrand crosslinks and discusses potential competition for DNA repair enzymes between platinum lesions and UV induced thymine dimers. This work provides a deep look into the mechanisms of cis-DDP and carboplatin in relation to DNA repair processes.

Key Features

Published by Springer, this book provides detailed research on platinum and other metal coordination compounds used in cancer chemotherapy.

The text explores the relationship between DNA excision repair and tumor cell resistance to platinum compounds.

It examines how combination chemotherapy using HU and Ara-C can inhibit repair systems to produce synergistic cell kills.

Research included covers the persistence of DNA interstrand crosslinks and the effects of cis-DDP and carboplatin.

The content analyzes the competition for DNA repair enzymes between platinum lesions and UV induced thymine dimers.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
29 February 1992
Listed Since
12 January 2007

Barcode

No barcode data available

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