CRC Press Targeted Therapies in Oncology

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world. About the Author Giuseppe Giaccone is a professor and associate director of the Lombardi Cancer Center at Georgetown University in Washington, D.C. He was previously the head of the Department of Medical Oncology, Free University Medical Center, Amsterdam, the Netherlands, and most recently the chief of the Medical Oncology Branch of the National Cancer Institute in Bethesda. Professor Giaccone has written more than 500 peer-reviewed scientific papers and several books and book chapters and is a board member of several international scientific journals. His fields of research include lung cancer and the development of novel anticancer agents. He was the chair of the Lung Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer until 2000. He has organized a number of international conferences, such as the Topoisomerase Symposia and the Targeted Anticancer Therapy conferences. Jean-Charles Soria is a professor of medicine at South-Paris University, France, and adjunct professor at the University of Texas MD Anderson Cancer Center. He is the chairman of the Early Drug Development Department at Gustave-Roussy, Villejuif, France. He is also a member of the Thoracic Multidisciplinary Committee at this institute. Professor Soria has authored over 300 peer-reviewed scientific papers, including publications as first or last author in the New England Journal of Medicine, the Journal of the National Cancer Institute, the Journal of Clinical Oncology, Clinical Cancer Research, and Annals of Oncology. He is a board member of several international scientific journals. His main research interests include early clinical development across solid tumors, pharmacodynamic biomarkers, lung cancer, and personalized medicine. He is also involved in translational research related to precision medicine and tumor progression, notably in lung cancer models (INSERM unit 981).