Humana Hypoxia and Cancer - Drug Discovery and Development Book

Explore the complex relationship between oxygen levels and tumor progression in Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities. This specialized text from the Cancer Drug Discovery and Development series examines how the imbalance between proliferating tumor cells and inefficient vasculature leads to hypoxia and anoxia in tumor tissues. Readers will gain a deep understanding of how intra-tumor hypoxia affects the biological behavior of cancer cells, contributing to therapy resistance and more invasive, metastatic phenotypes. The book covers the role of Hypoxia Inducible Factor 1 (HIF-1) as a master regulator of the transcriptional response to oxygen deprivation. This resource is designed for medical professionals and researchers looking to understand the hallmark of the malignant phenotype and the specific features of the tumor microenvironment.