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Academic Press Fragment Based Drug Design - Methods in Enzymology Vol 493

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Description

Fragment Based Drug Design: Tools, Practical Approaches, and Examples provides a necessary guide for researchers looking to implement fragment-based drug discovery (FBDD). While many reviews exist on the subject, this volume serves as a practical manual for those needing specific protocols to complement traditional high throughput screening methodologies. As part of the Methods in Enzymology series (Volume 493), this book offers direct instruction on conducting FBDD screens. It covers successful methods for generating leads from fragments, including the application of computational techniques, nuclear magnetic resonance, and surface plasmon resonance. This resource is designed to move beyond theory by providing hit-to-lead examples and actionable tools for the drug discovery process.

Key Features

Provides practical protocols and hand-holding guides for implementing fragment-based drug discovery as an orthogonal approach to traditional screening.

Includes detailed hit-to-lead examples to assist researchers in navigating the transition from fragment identification to lead generation.

Covers essential computational techniques used to support and enhance fragment-based drug design workflows.

Explains the application of nuclear magnetic resonance and surface plasmon resonance in conducting effective FBDD screens.

Offers a comprehensive collection of tools and successful methodologies for generating leads from chemical fragments.

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