Fragment-Based Methods in Drug Discovery: 1289 (Methods in Molecular Biology, 1289) - Image 1

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Humana Fragment-Based Methods in Drug Discovery: 1289 (Methods in Molecular Biology, 1289)

Name: Fragment-Based Methods in Drug Discovery: 1289 (Methods in Molecular Biology, 1289)
Brand: Humana
Price: 72.56 GBP
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15 black & white illustrations, 53 colou

Pharmacy - Dispensing

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Description

This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation. The second part discusses the technical aspects that various methods have used to simulate fragment binding to a target protein by using Monte Carlo, molecular dynamics, and docking algorithms. After simulations, fragments are assembled into molecules using a variety of approaches, which are explored next. A discussion of design strategies and consideration of drug-like properties is included as part of the design process at this stage. Finally, several examples of successful fragment-based drug design projects are presented. Written for the Methods in Molecular Biology series, this work contains the kind of detailed description and implementation advice to encourage success in the lab. Practical and cutting-edge, Fragment-Based Methods in Drug Discovery takes into account the great accomplishments in the field to provide an ideal guide for researchers continuing to investigate this exciting area of pharmacological study.

Product Specifications

Brand: Humana
Model: 15 black & white illustrations, 53 colou
Format: hardcover
ASIN: 1493924850
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Pharmacy - Dispensing
Domain: Amazon UK
Release Date: 24 February 2015
Listed Since: 19 December 2014

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Humana Fragment-Based Methods in Drug Discovery: 1289 (Methods in Molecular Biology, 1289)

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