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Formulierung und Bewertung eines schwimmenden In-situ-Gels aus Methotrexat

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£48.00 £45.60 £46.56 £47.52 £48.48 £49.44 £50.40 23 July 2026 05 August 2026 18 August 2026 31 August 2026 14 September 2026
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Price distribution over 54 days • 1 price levels

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54 days 0 14 27 41 54 £48 Days at Price

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Price levels: 1 different prices over 54 days

Description

Ziel der Studie war es, ein schwimmendes In-situ-Gel aus Methotrexat herzustellen und zu bewerten, um die Verweildauer im Magen zu verlängern und so eine nachhaltige Wirkstofffreisetzung im Magen-Darm-Trakt zu erreichen. Methotrexat ist ein Krebsmedikament. Es hat aufgrund seiner schnellen Freisetzung im Magen-Darm-Trakt (GIT) unerwünschte Nebenwirkungen. Das schwimmende In-situ-Gel wurde unter Verwendung von In-situ-gelbildenden Polymeren wie Natriumalginat und Pektin hergestellt. Die Kompatibilität von Wirkstoff und Hilfsstoffen wurde mittels FT-IR-Untersuchung geprüft. Zur Untersuchung der kombinierten Wirkung der Natriumalginatkonzentration (X1) und der Calciumcarbonatkonzentration (X2) wurde ein 3-stufiges 2-Faktoren-Vollfaktorielles Design angewendet. Die schwimmenden In-situ-Gele wurden hinsichtlich ihrer Schwimmverzögerungszeit, der prozentualen Wirkstofffreisetzung nach 1 Stunde und der prozentualen Wirkstofffreisetzung nach 12 Stunden bewertet. Zusätzlich zu den oben genannten Parametern wurden die schwimmenden In-situ-Gele auch hinsichtlich pH-Wert, Viskosität, Gelierfähigkeit, Schwimmzeit und Wirkstoffgehalt bewertet. Alle Formulierungen lieferten zufriedenstellende Ergebnisse hinsichtlich der Schwimmverzögerungszeit, der prozentualen Wirkstofffreisetzung nach 1 Stunde und nach 12 Stunden. Die Wirkstofffreisetzung hing von der Konzentration des in der Formulierung verwendeten Polymers und Calciumcarbonats ab.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
25 November 2025
Listed Since
27 November 2025

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No barcode data available

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