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Legami neuroendocrini e neurotrofici tra menopausa e rischio: Meccanismi neuroendocrini e neurotrofici che collegano la menopausa al rischio di malattie neurodegenerative

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Description

Le malattie neurodegenerative (ND), tra cui il morbo di Alzheimer e il morbo di Parkinson, sono caratterizzate da una progressiva perdita di neuroni che porta a compromissioni cognitive e motorie. Questi disturbi mostrano chiare differenze sesso-specifiche nella prevalenza e nella progressione, con prove sempre più evidenti che indicano la menopausa come un fattore critico che influenza la vulnerabilità femminile. Il calo degli estrogeni, del progesterone e di altri fattori neurotrofici durante la menopausa altera molteplici processi neuroprotettivi, contribuendo all'insorgenza e all'avanzamento della malattia.Questo libro evidenzia i principali meccanismi patologici alla base delle ND, come il misfolding proteico, lo stress ossidativo, la disfunzione mitocondriale, la neuroinfiammazione, l'apoptosi, la suscettibilità genetica e l'alterazione della barriera emato-encefalica. Il documento sottolinea i ruoli modulatori degli ormoni sessuali e del fattore di crescita insulino-simile-1 (IGF-1) attraverso vie di segnalazione genomiche e non genomiche che regolano la sopravvivenza neuronale e l'omeostasi cerebrale. Nel complesso, la menopausa viene presentata come una transizione biologica cruciale che aumenta la suscettibilità alle malattie neurodegenerative interrompendo le reti neuroendocrine e neurotrofiche interconnesse.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
06 February 2026
Listed Since
07 February 2026

Barcode

No barcode data available

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