Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease) - Image 1

£107.93

Springer Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)

Name: Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)
Brand: Springer
Price: 107.93 GBP
Availability: InStock

Neurology & Clinical Neurophysiology

It has never been this cheap. We have no record of a lower price.

£108 today · cheaper than every other day in the last 1 months

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 36 days • 36 data points

Historical

Generating forecast...

Price Distribution

Price distribution over 36 days • 1 price levels

Days at Price

Price Analysis

Most common price: £108 (36 days, 100.0%)

Price range: £108 - £108

Price levels: 1 different prices over 36 days

Description

Fondation Ipsen sponsored a meeting in Paris in February 2000 on the emerging paradigm-shift in our understanding of the major degenerative diseases which- affect the aging human brain. This book sumarizes our deliberations on some of these major neurodegenerative diseases that are characterized by protein depos- its, and that are due to the pathogenic gain of function of an otherwise normal neuronal protein. For each of the major human neurodegenerative diseases covered in this book -the most prominent being Alzheimer's disease -experimental models are described, including cell culture systems and animal models which range from the round worm, Caenorhabditis elegans, the fruitfly, Drosophila melanogaster, to rodents. Remarkably, in the sporadic forms of these human diseases, only a minor change in the level of production or turn-over of the relevant proteins is sufficient to cause disease in late adult-hood. Neurodegeneration in Alzheimer's disease, for example, usually results in symptoms and signs in the seventh to eighth decades. In contrast, the development of protein deposits in transgenic mice over-expressing the corresponding disease gene parallels the genetic forms of the human diseases in regard to its manifestation occuring half-way through its normal life-span, i. e. about 50 years in humans (the so-called "presenium") and 9 to 12 months in the mouse. Nevertheless, these models have served to elu- cidate many of the pathways underlying the human disease processes, for instance clarifying the neuronal origin of parenchymal and perivascular amyloid in Alzheimer's disease and Creutzfeldt-Jakob disease. From the Back Cover A fundamental change is occurring in the understanding of the major neurodegenerative disorders. Protein aggregation is a common emerging theme in diseases as diverse as Alzheimer's, Creutzfeld-Jakob, Parkinson's, and amyotrophic lateral sclerosis. If valid, then a small number of diagnostic and rational therapeutic strategies will emerge over the next few years, based on the common theme of modulation of the production, turnover and deposition of these aggregating proteins. The book provides insights into the cellular and animal models of these diseases, and how the molecular basis of neurodegeneration has become the preferred target of therapy.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3642074480
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Neurology & Clinical Neurophysiology
Domain: Amazon UK
Publication Date: 06 December 2010
Listed Since: 01 October 2010

Barcode

No barcode data available

Springer Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)

It has never been this cheap. We have no record of a lower price.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers

Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience)

Connections, Cognition and Alzheimer’s Disease (Research and Perspectives in Alzheimer's Disease)

Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders: Protein Aggregates In Neurodegenerative Disorders (Research And Perspectives In Alzheimer's Disease)

Protein Degradation in Health and Disease: 29 (Progress in Molecular and Subcellular Biology, 29)

Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology

Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation

Presenilins and Alzheimer’s Disease (Research and Perspectives in Alzheimer's Disease)

Neuroprotection Methods and Protocols: 399 (Methods in Molecular Biology, 399)

Neurodegenerative Disorders: A Clinical Guide

Diabetes, Insulin and Alzheimer's Disease (Research and Perspectives in Alzheimer's Disease)

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future: 2 (Advances in Predictive, Preventive and Personalised Medicine, 2)

The Proteasome in Neurodegeneration

Stem Cell-based Therapy for Neurodegenerative Diseases: 1266 (Advances in Experimental Medicine and Biology, 1266)

Research Progress in Alzheimer's Disease and Dementia: v. 3 (Nova Biomedical): Volume 3

Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research

Alzheimer’s Disease: A Physician’s Guide to Practical Management (Current Clinical Neurology)

Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Programmed Cells from Basic Neuroscience to Therapy: 20 (Research and Perspectives in Neurosciences, 20)

Mitochondrial Dynamics and Neurodegeneration

Alzheimer's Disease: Methods and Protocols: 32 (Methods in Molecular Medicine, 32)

Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics (Key Topics in Brain Research)

Neurodegenerative Diseases: 6 (Topics in Medicinal Chemistry, 6)

Ageing and Dementia: Current And Future Concepts: 62 (Journal of Neural Transmission. Supplementa, 62)