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Mejora de la solubilidad del fármaco mediante sistemas de administración basados en lípidos

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£51.00 £48.45 £49.47 £50.49 £51.51 £52.53 £53.55 25 July 2026 09 August 2026 25 August 2026 10 September 2026 26 September 2026
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Price distribution over 64 days • 1 price levels

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64 days 0 16 32 48 64 £51 Days at Price

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Price levels: 1 different prices over 64 days

Description

La formulación de fármacos se lleva a cabo con el objetivo principal de mejorar su biodisponibilidad. Los fármacos poco solubles en agua suponen un reto para los científicos de la formulación en cuanto a solubilidad y biodisponibilidad. Los sistemas de administración de fármacos basados en lípidos (LBDDS) son una de las tecnologías emergentes diseñadas para abordar estos retos. Los sistemas de administración basados en lípidos son cada vez más populares como portadores de fármacos debido a su capacidad para superar las barreras a la absorción oral. El objetivo del presente estudio era preparar una nueva formulación basada en lípidos de un fármaco poco soluble, el clorhidrato de ciprofloxacino (CLX), para aumentar su solubilidad de saturación y su velocidad de disolución y mejorar la biodisponibilidad, reduciendo al mismo tiempo la variabilidad sistémica. Se prepararon formulaciones a base de lípidos mediante la técnica de solubilización por fusión. Las formulaciones líquidas se convirtieron en un intermedio sólido por adsorción en un soporte inerte y se mezclaron con excipientes para su encapsulación. Se investigaron las propiedades en estado sólido, la morfología de la superficie y las características de liberación in vitro de las formulaciones lipídicas y se compararon con la formulación comercial.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
17 August 2022
Listed Since
18 August 2022

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No barcode data available

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