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LAP Lambert Academic Publishing Intracellular Delivery of Peptide Carriers, Substrates and Inhibitors: The non-invasive intracellular delivery of macromolecules

Name: Intracellular Delivery of Peptide Carriers, Substrates and Inhibitors: The non-invasive intracellular delivery of macromolecules
Brand: LAP Lambert Academic Publishing
Price: 71.0 GBP
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Biochemistry

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Biochemistry

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Description

The lipid bilayer, which comprises all cell membranes, represents a formidable barrier to the delivery of large hydrophilic molecules into cells. The ability to introduce information-rich molecules into cells is a challenge in the development of new therapeutics for diseases not currently amenable to small molecule intervention. This work focuses on the delivery of peptide-based molecules including; inhibitors, substrates and carriers into cells. A series of peptide-based inhibitors against caspase-3, an intracellular enzyme involved in apoptosis, were assessed for their cell membrane permeability. Proteolytic activation of a cell penetrating peptide was also investigated as a means of controlling the uptake of these carrier peptides into cells. Finally, the uptake and processing of an internally quenched Tat-caspase substrate was examined in cells undergoing apoptosis. This book may be of interest to scientists working in any area where large molecules need to be effectively delivered to cells. It may be of particular interest to those working on cell penetrating peptides, proteases or apoptosis.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3838344189
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biochemistry
Domain: Amazon UK
Release Date: 29 March 2010
Listed Since: 01 April 2010

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LAP Lambert Academic Publishing Intracellular Delivery of Peptide Carriers, Substrates and Inhibitors: The non-invasive intracellular delivery of macromolecules

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It has never been this cheap. We have no record of a lower price.

LAP Lambert Academic Publishing Intracellular Delivery of Peptide Carriers, Substrates and Inhibitors: The non-invasive intracellular delivery of macromolecules

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