Role of Intermediate and Low Penetrance Genes in Breast Cancer: The Mutational and Epigenetic Study - Image 1

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LAP Lambert Academic Publishing Role of Intermediate and Low Penetrance Genes in Breast Cancer: The Mutational and Epigenetic Study

Name: Role of Intermediate and Low Penetrance Genes in Breast Cancer: The Mutational and Epigenetic Study
Brand: LAP Lambert Academic Publishing
Price: 67.0 GBP
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Genetics

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The FHIT and Caveolin-1 genes are considered to be the intermediate penetrator genes that are involved in the development of Breast cancer. The basic aims of this thesis were to study the role of FHIT and CAV-1 gene in the development and progression of Breast cancer. The main aims of the study are: ? Detection of genetic aberrations in different exons of FHIT gene in Breast cancer patients using PCR- SSCP technique. ? Confirmation of detected mutations by Automated DNA Sequencing. ? Detection of genetic aberrations in different exons of CAV-1 gene and in Breast cancer patients using PCR- SSCP technique. ? Confirmation of detected mutations by Automated DNA Sequencing. ? Methylation Analysis of different exons of FHIT gene in Breast cancer patients using Standard PCR based Methylation Assays. ? Methylation Analysis of different exons of CAV-1 gene in Breast cancer patients using Standard PCR based Methylation Assays. ? Restriction fragment length polymorphism of ATM IVS10-6T?G in Breast cancer patients. ? Mutational detection of CHEK2 1100delC and NBS1 657del5 by Allele Specific Polymerase Reaction.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3838364813
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Genetics
Domain: Amazon UK
Release Date: 20 January 2011
Listed Since: 24 January 2011

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LAP Lambert Academic Publishing Role of Intermediate and Low Penetrance Genes in Breast Cancer: The Mutational and Epigenetic Study

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