A Biochemical Study of FOXM1 and TP53 Genes in Breast Cancer Patients - Image 1

£63.00

LAP Lambert Academic Publishing A Biochemical Study of FOXM1 and TP53 Genes in Breast Cancer Patients

Name: A Biochemical Study of FOXM1 and TP53 Genes in Breast Cancer Patients
Brand: LAP Lambert Academic Publishing
Price: 63.0 GBP
Availability: InStock

Genetics

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Description

Background: Breast cancer is a malignant tumor arising from the terminal duct lobular unit of the breast tissues. It is most prevalent malignancy in women and its incidence is increasing, approximately equals to 5-10%.Forkhead box M1 (FOXM1) is a transcription factor associates with proliferation signals and over-expressed in majority of human cancer involved breast. TP53 gene negatively regulates FOXM1 expression and therefore inactivation of TP53 in tumors could partially illustrate the phenomenon of FOXM1 over-expression in human cancers. Objectives: The main objective of the current study is to analyze FOXM1 and TP53 gene expressions levels in formalin fixed paraffin embedded tissues of breast cancer specimens.Subjects and Methods: One hundred formalin fixed paraffin embedded (FFPE) tissue samples of malignant breast tumors as well as 100 FFPE samples of normal breast tissues were investigated. Ages of patients (Mean ±SD) were 48.4 ± 10.90 year with a minimum to maximum of 20 -75 years. Total mRNA was extracted from FFPE blocks by using a specific kit.FOXM1 and TP53 gene expressions were estimated quantitatively by real time PCR.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659709611
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Genetics
Domain: Amazon UK
Release Date: 13 May 2015
Listed Since: 07 June 2015

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LAP Lambert Academic Publishing A Biochemical Study of FOXM1 and TP53 Genes in Breast Cancer Patients

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