Metal-Binding Drugs for Cancer Therapy: Drug Delivery and Membrane Transport of Thiosemicarbazones - Image 1

£57.00

LAP Lambert Academic Publishing Metal-Binding Drugs for Cancer Therapy: Drug Delivery and Membrane Transport of Thiosemicarbazones

Name: Metal-Binding Drugs for Cancer Therapy: Drug Delivery and Membrane Transport of Thiosemicarbazones
Brand: LAP Lambert Academic Publishing
Price: 57.0 GBP
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Description

Under normal circumstances, cellular metal homeostasis is tightly regulated. However, in malignancies, there is evidence that tumours possess alterations in the processing of biologically important transition metal ions, e.g., iron and copper. The de-regulation of metal homeostasis in cancer cells reveals a particular vulnerability to metal-depletion, which can be manipulated therapeutically by the use of novel chelators. The chelators, Dp44mT and Bp4eT, have recently been shown to be highly effective in terms of inhibiting tumour growth. Although studies have evaluated their mechanisms of action, the mechanism by which these agents are initially transported into cells to induce cytotoxicity is unknown and thus was investigated herein. These studies demonstrated that 14C-Bp4eT enter cells via a non-saturable linear uptake process, suggestive of passive diffusion, while the uptake of 14C-Dp44mT was saturable, indicating a carrier/receptor-mediated transport mechanism. Moreover, investigations also demonstrated that, unlike Bp4eT, the interactions of Dp44mT with HSA enhances chelator uptake into human cancer cells, increasing drug delivery and improving its anti-tumour efficacy.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659815039
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners
Domain: Amazon UK
Release Date: 06 January 2016
Listed Since: 30 January 2016

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LAP Lambert Academic Publishing Metal-Binding Drugs for Cancer Therapy: Drug Delivery and Membrane Transport of Thiosemicarbazones

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