Design and Synthesis of New Thiazole Derivatives as Anticancer Agents: p56 Lck Inhibitors - Image 1

£57.00

LAP Lambert Academic Publishing Design and Synthesis of New Thiazole Derivatives as Anticancer Agents: p56 Lck Inhibitors

Name: Design and Synthesis of New Thiazole Derivatives as Anticancer Agents: p56 Lck Inhibitors
Brand: LAP Lambert Academic Publishing
Price: 57.0 GBP
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Pharmacology

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Description

Thiazole is an important scaffold due to variety of pharmacological properties associated with the derivatives bearing this heterocyclic. Especially their importance in the cancer chemotherapy is unparallel. In our efforts to discover new chemical pharmacophore which may lead to formation of new anticancer agent. In the present study we have reported the synthesis of some new heterocyclic derivatives comprising substituted benzothiazole and 1,3,4-thiadiazole that linked by thiazole moiety. 2-Amino thiazoles are of interest because of their diverse biological activities and clinical applications. We have reported the new series of 2-Amino Thiazole analogues to target p56 lck(lymphocyte specific tyrosine kinase) inhibitors. Synthesized compounds were characterized and confirmed by IR, 1H-NMR and Mass spectral (MS) studies. For anticancer activity, all the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer in which Compound 8(a) shown better anticancer activity. The MTT assay was carried out which showed compound 8(a) better anticancer agent than other summarized.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3659571768
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 15 July 2019
Listed Since: 08 August 2019

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LAP Lambert Academic Publishing Design and Synthesis of New Thiazole Derivatives as Anticancer Agents: p56 Lck Inhibitors

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