Stress Signalling and Breast Cancer Development: The Roles of Breast Cancer Susceptibility Gene 1 Regulation and Glucocorticoid Receptor Gene Variations in Breast Tumour Development - Image 1

£51.00

VDM Verlag Stress Signalling and Breast Cancer Development: The Roles of Breast Cancer Susceptibility Gene 1 Regulation and Glucocorticoid Receptor Gene Variations in Breast Tumour Development

Name: Stress Signalling and Breast Cancer Development: The Roles of Breast Cancer Susceptibility Gene 1 Regulation and Glucocorticoid Receptor Gene Variations in Breast Tumour Development
Brand: VDM Verlag
Price: 51.0 GBP
Availability: InStock

Biochemistry

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Description

Breast cancer is one of the major causes of premature mortality in women. Research suggests that psychological stress may be a contributing factor to breast cancer development. However, the molecular mechanisms responsible for such an association have yet to be clearly defined. This research work outlines the current state of knowledge on the relationship between stress and breast cancer and focuses on identifying novel molecular signals which may contribute to the effect of stress on breast physiology. With the help of molecular techniques, The Breast Cancer Susceptibility Gene 1 (BRCA1), an important regulator of the genetic processes responsible for tumor development, is identified as a target of stress signalling. In addition, the currently unknown role of genetic modifiers in the relationship between stress and breast cancer is addressed through the development of an epidemiological study examining if stress- susceptible individuals are at an increased risk of developing breast cancer. An integrative model, incorporating genetic stress susceptibility and downstream changes in the expression and activity of molecular regulators is proposed.

Product Specifications

Brand: VDM Verlag
Format: paperback
ASIN: 3639316681
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biochemistry
Domain: Amazon UK
Release Date: 10 March 2011
Listed Since: 15 March 2011

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VDM Verlag Stress Signalling and Breast Cancer Development: The Roles of Breast Cancer Susceptibility Gene 1 Regulation and Glucocorticoid Receptor Gene Variations in Breast Tumour Development

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