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LAP Lambert Academic Publishing Evaluation of Modified HPMC based Gel: Local and Systemic Use

Name: Evaluation of Modified HPMC based Gel: Local and Systemic Use
Brand: LAP Lambert Academic Publishing
Price: 55.0 GBP
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Description

The aim of this work is to develop topical hydrogels containing diclofenac potassium (DP) at 1 % w/v concentration using conventional hydrophilic hydroxypropyl methyl cellulose (HPMC, 50cPs) and different grades of modified hydrophobic hydroxypropyl methyl cellulose (HPMC, 60L, 60M, 90L and 90 M grade). Small quantity of hydrophobic HPMC is good enough to prepare gel of satisfactory quality. Hydrophobic formulations of higher viscosity with small quantity of polymer show higher release compared to hydrophilic formulations of lower viscosity with higher polymer concentration. Kinetic analysis of in vitro release profile was done by comparing the goodness-of-fit of some empirical/ semi-empirical and statistical models. From the accuracy point of view, direct fitting is preferred to transformed linear fit methods. Further, it was observed that the log-logistic distribution was the best fit for hydrophobic formulations. For hydrophilic ones, the semi-empirical models and Weibull distribution worked best, although log-logistic also showed a close fit. Hydrophobic formulations with enhancers are found to have the most promising anti-nociceptive activity.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 365916402X
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine
Domain: Amazon UK
Release Date: 22 June 2012
Listed Since: 22 June 2012

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LAP Lambert Academic Publishing Evaluation of Modified HPMC based Gel: Local and Systemic Use

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It has never been this cheap. We have no record of a lower price.

LAP Lambert Academic Publishing Evaluation of Modified HPMC based Gel: Local and Systemic Use

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

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