Alternative Splicing and Disease: 44 (Progress in Molecular and Subcellular Biology, 44) - Image 1

£140.65

Springer Alternative Splicing and Disease: 44 (Progress in Molecular and Subcellular Biology, 44)

Name: Alternative Splicing and Disease: 44 (Progress in Molecular and Subcellular Biology, 44)
Brand: Springer
Price: 140.65 GBP
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Description

Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy. From the Back Cover Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3642070817
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners
Domain: Amazon UK
Release Date: 30 November 2010
Listed Since: 01 October 2010

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Springer Alternative Splicing and Disease: 44 (Progress in Molecular and Subcellular Biology, 44)

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