Cellular Regulation of Glutamate Receptors in Central Neurons: Intracellular Signaling, Receptor Trafficking, Protease Proteolysis - Image 1

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VDM Verlag Cellular Regulation of Glutamate Receptors in Central Neurons: Intracellular Signaling, Receptor Trafficking, Protease Proteolysis

Name: Cellular Regulation of Glutamate Receptors in Central Neurons: Intracellular Signaling, Receptor Trafficking, Protease Proteolysis
Brand: VDM Verlag

Biological Science

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Description

Our brain houses the network of 10 billion neurons, and glutamate is the major neurotransmitter mediating rapid and excitatory synaptic transmission. Interestingly, glutamate receptor channels travel between intracellular compartments in response to various extracellular stimulations. Changes in the levels or localization of glutamate receptor profoundly affect synaptic activity and signal transduction. Neurological disorders, such as schizophrenia, depression and stroke, result from aberrant glutamate signaling in certain brain regions. Therefore, research on glutamate receptor is of particular interest in understanding brain function under normal and pathological conditions. This book dissects three cellular aspects of how glutamate receptors are modulated in cortical neurons: neuromodulator-mediated signaling, cytoskeleton-based delivery of ion channels and protease-dependent degradation of receptors. Knowledge here may shed light on identifying new drug targets for treating brain disorders that associated with impaired glutamate system.

Product Specifications

Brand: VDM Verlag
Format: paperback
ASIN: 3639152611
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biological Science
Domain: Amazon UK
Release Date: 21 May 2009
Listed Since: 02 June 2009

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VDM Verlag Cellular Regulation of Glutamate Receptors in Central Neurons: Intracellular Signaling, Receptor Trafficking, Protease Proteolysis

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