Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141) - Image 1

£341.86

Springer Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141)

Name: Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141)
Brand: Springer
Price: 341.86 GBP
Availability: InStock

General Medical Issues

Price History & Forecast

Last 6 days • 6 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 6 days • 1 price levels

Days at Price

Price Analysis

Most common price: £342 (6 days, 100.0%)

Price range: £342 - £342

Price levels: 1 different prices over 6 days

Description

It is now widely accepted that glutamate is the major excitatory neurotrans- mitter in the mammalian central nervous system. The main criteria for accept- ing a molecule as a chemical transmitter appear to be fulfilled at several synapses: Glutamate mimics the action of the natural transmitter in the post- synaptic neuron (CURTIS et al. 1959), glutamate is present in presynaptic ele- ments (OTTERSEN and STORM-MATHISEN 1984), and glutamate is released from central neurons in an activity-dependent manner (BRADFORD 1970). The postsynaptic receptors that mediate the effects of glutamate are markedly diverse. Based on their activation by agonists that act more selec- tively than the natural transmitter itself, a-amino-3-hydroxy-5-methyl- isoxazolepropionate (AMPA) receptors, kainate receptors, and N-methyl-D- aspartate (NMDA) receptors can be distinguished. Molecular cloning has revealed additional structural diversity. To date, almost 20 glutamate receptor subunit genes have been identified, and an even larger number of splice vari- ants and edited versions are present in the mammalian brain. Analysis of synaptic transmission revealed that "the" excitatory synapse does not exist. Glutamatergic synapses in different circuitries differ substan- tially in their signaling properties, although they use the same transmitter. We have learned that cellular, subcellular, and molecular factors determine synap- tic function, and that glutamate receptor subunit diversity is of direct relevance in shaping the unique signaling properties of a glutamatergic synapse.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3642085393
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues
Domain: Amazon UK
Release Date: 01 December 2010
Listed Since: 01 October 2010

Barcode

No barcode data available

Springer Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141)

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141)

Humana - The Metabotropic Glutamate Receptors Book

Cellular Regulation of Glutamate Receptors in Central Neurons: Intracellular Signaling, Receptor Trafficking, Protease Proteolysis

The Glutamate Receptors (The Receptors)

Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology (Pharmaceutical Science Series)

Excitatory Amino Acids: Clinical Results with Antagonists

Excitotoxicity in Neurological Diseases: New Therapeutic Challenge

Metabotropic Glutamate Receptors: Classification, Structure and Roles in Disease

The Glutamate/GABA-Glutamine Cycle: Amino Acid Neurotransmitter Homeostasis: 13 (Advances in Neurobiology, 13)

METABOTROPIC GLUTAMATE RECEPTORS MOLE: Molecular Mechanisms, Role in Neurological Disorders & Pharmacological Effects (Neuroscience Research Progress)

Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS (Endocrine Updates S)

Nova Science Glutamate Functions Regulation & Disorders Book

Humana Glutamate Receptors: Methods and Protocols 1941

Biochemical Approaches for Glutamatergic Neurotransmission: 130 (Neuromethods, 130)

Biochemical Approaches for Glutamatergic Neurotransmission: 130 (Neuromethods, 130)

The Glutamate/GABA-Glutamine Cycle: Amino Acid Neurotransmitter Homeostasis: 13 (Advances in Neurobiology, 13)

Synaptosomes: 141 (Neuromethods, 141)

Excitatory Amino Acids and Second Messenger Systems: 3 (Ernst Schering Foundation Symposium Proceedings)

Glutamate and Addiction (Contemporary Clinical Neuroscience)

Humana mGLU Receptors: 31 (The Receptors, 31) - Medical Book

The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology: 29 (Frontiers in Neuroscience)

The Glutamate Synapse as a Therapeutic Target (Volume 116) (Progress in Brain Research, Volume 116)

Molecular Mechanisms of Neurotransmitter Release (Contemporary Neuroscience)

Springer Glial Amino Acid Transporters: 16 Neurobiology Book