Excitotoxicity in Neurological Diseases: New Therapeutic Challenge - Image 1

£110.66

Springer Excitotoxicity in Neurological Diseases: New Therapeutic Challenge

Name: Excitotoxicity in Neurological Diseases: New Therapeutic Challenge
Brand: Springer
Price: 110.66 GBP
Availability: InStock

Neurology & Clinical Neurophysiology

This is the most expensive it has ever been. Walk away.

£111 today · previous high £111 · all-time low £106

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 526 days • 526 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 526 days • 4 price levels

Days at Price

Current Price

Price Analysis

Most common price: £107 (261 days, 49.6%)

Price range: £106 - £111

Price levels: 4 different prices over 526 days

Description

It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die in neurodegenerative disorders. Evidence accumulated in the past 20 years indicated that the major excitatory neurotransmitter glutamate may play a role as neurotoxin in several conditions. In particular, the glutamatergic system dysfunction seems to be an early event working as a common pathway in the pathogenesis ofa large number ofacute and chronic neurological disorders, in strict conjunction with other important mechanisms, such as oxidative stress and energetic failure, and probably triggered by different mechanisms in various diseases. In consideration of that, drug discovery efforts over the last decade have been focused on the search for drugs that either reduce glutamate synaptic levels or block its postsynaptic effects. Despite numerous reviews on basic mechanisms and clinical aspects ofthe excitotoxic phenomenon, so far no comprehensive book has covered the topic in all its complexity, starting from basic pharmacological mechanisms, to .animal models of diseases and finally to clinical pathogenic and therapeutic implications.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 146134736X
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Neurology & Clinical Neurophysiology
Domain: Amazon UK
Publication Date: 17 October 2012
Listed Since: 03 March 2013

Barcode

No barcode data available

Springer Excitotoxicity in Neurological Diseases: New Therapeutic Challenge

This is the most expensive it has ever been. Walk away.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Humana - The Metabotropic Glutamate Receptors Book

EXCITOTOXICITY FUNDAMENTAL: Fundamental Concepts, Pathophysiology & Treatment Strategies (Neuroscience Research Progress)

Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141)

Ionotropic Glutamate Receptors in the CNS: 141 (Handbook of Experimental Pharmacology, 141)

Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS (Endocrine Updates S)

Cellular Regulation of Glutamate Receptors in Central Neurons: Intracellular Signaling, Receptor Trafficking, Protease Proteolysis

Excitatory Amino Acids: Clinical Results with Antagonists

The Glutamate Synapse as a Therapeutic Target (Volume 116) (Progress in Brain Research, Volume 116)

The Glutamate/GABA-Glutamine Cycle: Amino Acid Neurotransmitter Homeostasis: 13 (Advances in Neurobiology, 13)

Metabotropic Glutamate Receptors: Classification, Structure and Roles in Disease

Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology (Pharmaceutical Science Series)

Biochemical Approaches for Glutamatergic Neurotransmission: 130 (Neuromethods, 130)

Biochemical Approaches for Glutamatergic Neurotransmission: 130 (Neuromethods, 130)

The Glutamate Receptors (The Receptors)

New Technologies for Glutamate Interaction: Neurons and Glia: 207 (Neuromethods, 207)

METABOTROPIC GLUTAMATE RECEPTORS MOLE: Molecular Mechanisms, Role in Neurological Disorders & Pharmacological Effects (Neuroscience Research Progress)

Excitotoxins: Proceedings of an International Symposium held at The Wenner-Gren Center, Stockholm, August 26–27, 1982: 39 (Wenner-Gren Center International Symposium Series)

Molecular Mechanisms of Neurotransmitter Release (Contemporary Neuroscience)

Dopamine - Glutamate Interactions in the Basal Ganglia: 49 (Frontiers in Neuroscience)

Neuroglia in Neurodegenerative Diseases: 1175 (Advances in Experimental Medicine and Biology, 1175)

Nitric Oxide in Brain Development, Plasticity, and Disease (Volume 118) (Progress in Brain Research, Volume 118)

Glutamate and Addiction (Contemporary Clinical Neuroscience)

KAINIC ACID NEUROTOXIC PROPERTIES BI: Neurotoxic Properties, Biological Sources & Clinical Applications (Biochemistry Research Trends)

Synaptosomes: 141 (Neuromethods, 141)