Polyglutamine Disorders: 1049 (Advances in Experimental Medicine and Biology, 1049) - Image 1

£93.13

Springer Polyglutamine Disorders: 1049 (Advances in Experimental Medicine and Biology, 1049)

Name: Polyglutamine Disorders: 1049 (Advances in Experimental Medicine and Biology, 1049)
Brand: Springer
Price: 93.13 GBP
Availability: InStock

Neurology & Clinical Neurophysiology

It has never been this cheap. We have no record of a lower price.

£93 today · cheaper than every other day in the last 3 months

NEW HERE?

Amazon shows you one price. We show you all of them.

Tosheroon watches Amazon prices so you don't have to. Every product on Amazon has a price history — we make it visible. Set the price you'd actually pay, and we'll email you the second it gets there. No app, no account, one email.

WHAT'S ON THIS PAGE

↓ Price chart
when this has been cheap or pricey

↓ Forecast
where the price is heading next

↓ Statistics
all-time high & low, recent range

↑ Price alert
name your number, we'll email you

Price History & Forecast

Grey patches = out of stock. Cheaper = lower on the chart. Hover for exact prices.

Last 69 days • 69 data points (No recent data available)

Historical

Generating forecast...

Price Distribution

Price distribution over 69 days • 2 price levels

Days at Price

Current Price

Price Analysis

Most common price: £97 (39 days, 56.5%)

Price range: £93 - £97

Price levels: 2 different prices over 69 days

Description

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression. From the Back Cover This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression. About the Author Clevio Nobrega Ph.D. and Luis Pereira de Almeida Ph.D. University of Coimbra, Center for Neurosciences and Cell Biology, FMUC, Coimbra, Portugal

Product Specifications

Brand: Springer
Format: paperback
ASIN: 3319891030
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Neurology & Clinical Neurophysiology
Domain: Amazon UK
Release Date: 06 June 2019
Listed Since: 25 January 2019

Barcode

No barcode data available

Springer Polyglutamine Disorders: 1049 (Advances in Experimental Medicine and Biology, 1049)

It has never been this cheap. We have no record of a lower price.

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

Huntington's Disease: Prevalence, Pathogenesis & Treatment (Neurology-laboratory and Clinical Research Developments)

Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience)

RNA Metabolism in Neurodegenerative Diseases: 20 (Advances in Neurobiology, 20)

Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers

Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease: 22 (Current Topics in Behavioral Neurosciences, 22)

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy: 217 (Advances in Anatomy, Embryology and Cell Biology, 217)

Stem Cell-based Therapy for Neurodegenerative Diseases: 1266 (Advances in Experimental Medicine and Biology, 1266)

Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation

Neurodegenerative Disorders: Loss of Function Through Gain of Function (Research and Perspectives in Alzheimer's Disease)

Multiple System Atrophy

Neurodegenerative Diseases: 6 (Topics in Medicinal Chemistry, 6)

NEUROPATHOLOGY: New Research (Neuroscience Research Progress; Neurology - Laboratory and Clinical Research Developments)

Advances in Plasma Physics Research: v. 2: Vol 2: Volume 2

Creutzfeldt-Jakob Disease: New Research

Neuroprotective Signal Transduction (Contemporary Neuroscience)

Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future: 2 (Advances in Predictive, Preventive and Personalised Medicine, 2)

Translational Research in Muscular Dystrophy

Neuroacanthocytosis Syndromes

Neurodegenerative Disorders: A Clinical Guide

Atypical Parkinsonian Disorders: Clinical and Research Aspects (Current Clinical Neurology)

Protein Degradation in Health and Disease: 29 (Progress in Molecular and Subcellular Biology, 29)

Doenças Neurodegenerativas: Kuru, Alzheimer, Parkinson, Huntington: Doenças neurodegenerativas em humanos e animais

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future: 2 (Advances in Predictive, Preventive and Personalised Medicine, 2)