£180.99

Dextromethorphan: Pharmacology, Clinical Uses & Health Effects

Pharmacology

Price data last checked 90 day(s) ago - refreshing...

View at Amazon

Price History & Forecast

Last 1 days • 1 data points (No recent data available)

Historical

Generating forecast...

Not enough data points to display chart (need at least 2 points)

Price Distribution

Price distribution over 1 days • 1 price levels

Days at Price

Price Analysis

Most common price: £181 (1 days, 100.0%)

Price range: £181 - £181

Price levels: 1 different prices over 1 days

Description

Dextromethorphan (DM) is an over-the-counter antitussive drug that is also used as one of the active ingredients in many cold and cough medicines. In recent years, DM has also been used in other medicines, ranging from pain relief (as either the primary analgesic or an opioid potentiater) over psychological applications to the treatment of addiction. Pharmacodynamics of DM have been gradually discovered with the elucidation of the following properties, including uncompetitive NMDA receptor antagonist, σ1 and σ2 sigma receptor agonists, α3β4-nACh receptor antagonist, and others. DM is transformed to its primary and active metabolite dextrorphan predominantly via the metabolic enzyme cytochrome P450 (CYP) 2D6. Hence, DM is the first-choice substrate for CYP2D6 phenotyping because it is relatively safe and possesses many favorable pharmacokinetic characteristics for a marker substrate. This book aims to meet the needs of basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand the pharmacology of DM and its clinical uses. The contributing authors are basic scientists, pharmacologists, pharmacists and on-service physicians in neuro-psychiatric, anesthesiologic and hepatologic fields from the Czech Republic, Austria, the United States, and China. As a collection of masterpieces by well-known experts, this book presents current research in the study of DM, focusing on its pharmacology, clinical uses and health effects. Topics discussed in this compilation include the new pharmacological application of DM; pharmacogenetics of DM; pharmacodynamics and toxicological profiles of DM; long cutaneous block by lidocaine and DM; toxic and beneficial effects of DM on the central nervous system; pharmacokinetics of DM and drug interactions; DM as a probe drug for CYP2D6 and CYP3A4 phynotyping; evaluation of CYP2D6 in DM-herb interactions; and clinical uses and health effects of DM.

Product Specifications

Format: hardcover
ASIN: 163484016X
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 01 January 2016
Listed Since: 15 October 2015

Barcode

No barcode data available

Dextromethorphan: Pharmacology, Clinical Uses & Health Effects

Price History & Forecast

Price Distribution

Price Analysis

Description

Product Specifications

Barcode

Similar Products You Might Like

ADVANCED SEMICONDUCTING MATERIALS AND D: Biochemistry, Pharmacology & Health Implications (Biochemistry Research Trends)

Commonly Used Drugs by Nova Science Publishers - Pharmacology

Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs: A comprehensive review on their mode of action, treatment of abuse and intoxication

Drugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology

Handbook of Research on Medicinal Chemistry: Innovations and Methodologies

Introduction to Drug Disposition and Pharmacokinetics

Drug Metabolism in Diseases

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Humana Cytochrome P450: In Vitro Methods and Protocols Book

Academic Press - How Synthetic Drugs Work Pharmacology Book

Translational ADMET for Drug Therapy: Principles, Methods, and Pharmaceutical Applications

Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism

An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions

Drug Discovery for the Treatment of Addiction: Medicinal Chemistry Strategies

Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications

Advances in Medicinal Chemistry Research (New Developments in Medical Research)

Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set

Clinical Handbook of Psychotropic Drugs

Humana Optimization in Drug Discovery: In Vitro Methods Book

Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology)

Monoamine Oxidase Inhibitors: Clinical Pharmacology, Benefits, & Potential Health Risks

Substance Use Disorders in Adolescents and Young Adults: A Manual for Pediatric and Primary Care Clinicians

Humana Methods for Novel Psychoactive Substance Analysis

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists