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Eicosanoids, Inflammation and Chronic Inflammatory Diseases: Pathophysiology, Health Effects & Targets for Therapies

Physiotherapy

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Eicosanoids constitute a large and expanding family of bioactive lipids synthesized from polyunsaturated fatty acids (PUFA) to either pro-inflammatory omega-6 arachidonic acid (AA) or anti-inflammatory omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In these last cases, two essential fatty acids (FAs) (ω-6 linoleic acid (C18:2n6) and ω-3 linolenic acid (LA) (C18:3n3) are utilized as substrates and a series of desaturase and elongase enzymes are essential for their production. Among these different members, the AA-derived eicosanoids operate as potent signaling mediators that provide an efficient way for cells to respond to various stimuli. As a result, they act as part of a complex regulatory network and control a number of important physiological processes. Some of these processes include: smooth muscle tone; vascular permeability; platelet aggregation; broncho-constriction/dilation; intestine motility.

Product Specifications

Format: hardcover
ASIN: 1634827996
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Physiotherapy
Domain: Amazon UK
Release Date: 01 September 2015
Listed Since: 23 April 2015

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Eicosanoids, Inflammation and Chronic Inflammatory Diseases: Pathophysiology, Health Effects & Targets for Therapies

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