Humana Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma (Current Clinical Pathology)

Product Description Table of Contents: 1. Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in MelanomaMichael J. Murphy 2. Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play Jochen Utikal, Jürgen C. Becker, and Selma Ugurel 3. Molecular Pathogenesis of Melanoma: Established and Novel PathwaysPaolo Antonio Ascierto, Maria Libera Ascierto, Mariaelena Capone, Zendee Elaba, Michael J. Murphy, and Giuseppe Palmieri 4. Staging of MelanomaZendee Elaba, Michael J. Murphy, Philip Kerr, and Jane M. Grant-Kels 5. Clinical and Histopathological Parameters in MelanomaCheryl Bilinski, Avery LaChance, and Michael J. Murphy 6. Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic NeoplasmsMinoru Takata 7. mRNA Biomarkers in MelanomaGiovanna Chiorino and Maria Scatolini 8. Epigenetic Biomarkers in MelanomaSuhu Liu, Suping Ren, Paul M. Howell Jr., and Adam I. Riker 9. microRNA Biomarkers in MelanomaJim Kozubek, Faseeha Altaf and Soheil S. Dadras 10. MicroRNAs as Biomarkers and Therapeutic Targets in MelanomaDaniel W. Mueller, Anja K. Bosserhoff 11. Mitochondrial DNA Biomarkers in MelanomaMark L. Steinberg 12. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) DiagnosisSteven J. Ohsie, Basil A. Horst, Alister Cochran, and Scott W. Binder 13. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) PrognosticationBasil A. Horst, Steven J. Ohsie, Alister Cochran, and Scott W. Binder 14. Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based StrategiesMichael J. Murphy, Karim Rezaul, and David K. Han 15. Serological Biomarkers in MelanomaMel Ziman, Michael Millward, Robert Pearce, and Mark Lee 16. Molecular Markers of Lymph Node Disease in MelanomaSandro Pasquali, Augustinus P.T. van der Ploeg, and Simone Mocellin 17. Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of TumorigenicityQiuzhen Liu, Marianna Sabatino, David F. Stroncek, Ping Jin, Francesco M. Marincola, and Ena Wang 18. Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue MarginsAmanda Phelps and Michael J. Murphy 19. Chemotherapy for MelanomaHedwig Stanisz, Thomas Vogt, and Knuth Rass 20. Molecular-Targeted Therapy for MelanomaAlessia E. Russo, Ylenia Bevelacqua, Andrea Marconi, Andrea Veronesi, and Massimo Libra 21. Anti-Angiogenesis Therapy for MelanomaRoberta Ferraldeschi and Paul Lorigan 22. Immunological Biomarkers and Immunotherapy for MelanomaJochen T. Schaefer 23. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An OverviewAhmad A. Tarhini and John M. Kirkwood Review From the reviews:“This is a comprehensive overview of biomarkers as they relate to pathogenesis and clinical utility in the diagnosis, staging, and treatment of melanoma. … The audience is practitioners specializing in melanoma, including dermatologists, surgeons, and oncologists, as well as researchers in the field. … book broadly explores the role of molecular diagnostic techniques and specific biomarkers which may serve to facilitate more accurate diagnoses and identify early-stage melanoma patients with high risk for metastasis. … I highly recommend this book for melanoma clinicians and researchers.” (Susan M. Swetter, Doody’s Book Reviews, July, 2012) From the Back Cover This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a grea